Prof. John A. Pelesko, a mathematician with the University of Delaware, describes self-assembly and offers his views on how understanding of models and mathematics of self-assembly can improve man-made engineering. Prof. Pelesko discussed how the term "self-assembly" is used in many ways by many different scientific fields, and highlights work by prominent researchers in self-assembly such as Harvard Universitiy's Prof. G. Whitesides, Caltech's Dr. P.W.K. Rothemund, and Duke University's Prof. J. Reif.